270472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2306160..2306682 Replicon chromosome
Accession NZ_CP117317
Organism Salmonella enterica subsp. enterica serovar Derby strain RM002

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQQ14_RS11150 Protein ID WP_000221343.1
Coordinates 2306160..2306444 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQQ14_RS11155 Protein ID WP_000885424.1
Coordinates 2306434..2306682 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ14_RS11130 (2302235) 2302235..2303743 - 1509 WP_048348841.1 FAD-dependent oxidoreductase -
PQQ14_RS11135 (2303788) 2303788..2304276 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQQ14_RS11140 (2304469) 2304469..2305548 + 1080 WP_023231841.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQQ14_RS11145 (2305600) 2305600..2305989 - 390 WP_023206403.1 RidA family protein -
PQQ14_RS11150 (2306160) 2306160..2306444 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ14_RS11155 (2306434) 2306434..2306682 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ14_RS11160 (2307357) 2307357..2307779 + 423 WP_048348840.1 PTS sugar transporter subunit IIA -
PQQ14_RS11165 (2307839) 2307839..2308120 + 282 WP_023218025.1 PTS sugar transporter subunit IIB -
PQQ14_RS11170 (2308132) 2308132..2309523 + 1392 WP_274881736.1 PTS galactitol transporter subunit IIC -
PQQ14_RS11175 (2309600) 2309600..2311111 + 1512 WP_023231843.1 FGGY family carbohydrate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2304469..2321578 17109


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270472 WP_000221343.1 NZ_CP117317:c2306444-2306160 [Salmonella enterica subsp. enterica serovar Derby]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270472 WP_000885424.1 NZ_CP117317:c2306682-2306434 [Salmonella enterica subsp. enterica serovar Derby]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References