Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 816109..816769 Replicon chromosome
Accession NZ_CP117317
Organism Salmonella enterica subsp. enterica serovar Derby strain RM002

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQQ14_RS03910 Protein ID WP_000244756.1
Coordinates 816356..816769 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQQ14_RS03905 Protein ID WP_000351186.1
Coordinates 816109..816375 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ14_RS03885 (812038) 812038..813471 - 1434 WP_023232670.1 6-phospho-beta-glucosidase BglA -
PQQ14_RS03890 (813629) 813629..813940 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQQ14_RS03895 (814104) 814104..814763 + 660 WP_000250289.1 hemolysin III family protein -
PQQ14_RS03900 (814879) 814879..815859 - 981 WP_023232672.1 tRNA-modifying protein YgfZ -
PQQ14_RS03905 (816109) 816109..816375 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQQ14_RS03910 (816356) 816356..816769 + 414 WP_000244756.1 protein YgfX Toxin
PQQ14_RS03915 (816822) 816822..817343 - 522 WP_001055885.1 flavodoxin FldB -
PQQ14_RS03920 (817456) 817456..818352 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQQ14_RS03925 (818376) 818376..819089 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ14_RS03930 (819095) 819095..820828 + 1734 WP_023181521.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270470 WP_000244756.1 NZ_CP117317:816356-816769 [Salmonella enterica subsp. enterica serovar Derby]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270470 WP_000351186.1 NZ_CP117317:816109-816375 [Salmonella enterica subsp. enterica serovar Derby]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References