Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 3209469..3209991 Replicon chromosome
Accession NZ_CP117312
Organism Salmonella enterica subsp. enterica serovar Derby strain RM003

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQP99_RS15490 Protein ID WP_000221343.1
Coordinates 3209707..3209991 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP99_RS15485 Protein ID WP_000885424.1
Coordinates 3209469..3209717 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP99_RS15465 (3205040) 3205040..3206551 - 1512 WP_023231843.1 FGGY family carbohydrate kinase -
PQP99_RS15470 (3206628) 3206628..3208019 - 1392 WP_023218026.1 PTS galactitol transporter subunit IIC -
PQP99_RS15475 (3208031) 3208031..3208312 - 282 WP_023218025.1 PTS sugar transporter subunit IIB -
PQP99_RS15480 (3208372) 3208372..3208794 - 423 WP_048348840.1 PTS sugar transporter subunit IIA -
PQP99_RS15485 (3209469) 3209469..3209717 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP99_RS15490 (3209707) 3209707..3209991 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP99_RS15495 (3210162) 3210162..3210551 + 390 WP_023206403.1 RidA family protein -
PQP99_RS15500 (3210603) 3210603..3211682 - 1080 WP_023231841.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP99_RS15505 (3211875) 3211875..3212363 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP99_RS15510 (3212408) 3212408..3213916 + 1509 WP_048348841.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3194570..3216773 22203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270466 WP_000221343.1 NZ_CP117312:3209707-3209991 [Salmonella enterica subsp. enterica serovar Derby]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270466 WP_000885424.1 NZ_CP117312:3209469-3209717 [Salmonella enterica subsp. enterica serovar Derby]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References