Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2141281..2141901 Replicon chromosome
Accession NZ_CP117312
Organism Salmonella enterica subsp. enterica serovar Derby strain RM003

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP99_RS10315 Protein ID WP_001280991.1
Coordinates 2141281..2141499 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q7HJ94
Locus tag PQP99_RS10320 Protein ID WP_023231707.1
Coordinates 2141527..2141901 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP99_RS10275 (2136504) 2136504..2137073 + 570 WP_000779802.1 YbaY family lipoprotein -
PQP99_RS10280 (2137106) 2137106..2137495 - 390 WP_000961285.1 MGMT family protein -
PQP99_RS10290 (2137726) 2137726..2139276 - 1551 WP_023231708.1 EAL domain-containing protein -
PQP99_RS10295 (2139501) 2139501..2139761 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP99_RS10300 (2139767) 2139767..2139907 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP99_RS10305 (2139963) 2139963..2140433 - 471 WP_000136183.1 YlaC family protein -
PQP99_RS10310 (2140551) 2140551..2141102 - 552 WP_274880208.1 maltose O-acetyltransferase -
PQP99_RS10315 (2141281) 2141281..2141499 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP99_RS10320 (2141527) 2141527..2141901 - 375 WP_023231707.1 Hha toxicity modulator TomB Antitoxin
PQP99_RS10325 (2142397) 2142397..2145546 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP99_RS10330 (2145569) 2145569..2146762 - 1194 WP_023231706.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270461 WP_001280991.1 NZ_CP117312:c2141499-2141281 [Salmonella enterica subsp. enterica serovar Derby]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14439.24 Da        Isoelectric Point: 5.1444

>AT270461 WP_023231707.1 NZ_CP117312:c2141901-2141527 [Salmonella enterica subsp. enterica serovar Derby]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q7HJ94

References