Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1450425..1450975 Replicon chromosome
Accession NZ_CP117312
Organism Salmonella enterica subsp. enterica serovar Derby strain RM003

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag PQP99_RS07020 Protein ID WP_001199743.1
Coordinates 1450667..1450975 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag PQP99_RS07015 Protein ID WP_000016244.1
Coordinates 1450425..1450664 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP99_RS06985 (1446347) 1446347..1446877 + 531 WP_023232248.1 gluconokinase -
PQP99_RS06990 (1446905) 1446905..1447924 - 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
PQP99_RS07000 (1448682) 1448682..1449659 + 978 WP_223156438.1 IS630 family transposase -
PQP99_RS07005 (1449679) 1449679..1449987 + 309 Protein_1371 DUF4942 domain-containing protein -
PQP99_RS07010 (1450064) 1450064..1450312 + 249 WP_000168385.1 ribbon-helix-helix domain-containing protein -
PQP99_RS07015 (1450425) 1450425..1450664 + 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PQP99_RS07020 (1450667) 1450667..1450975 + 309 WP_001199743.1 CcdB family protein Toxin
PQP99_RS07025 (1451410) 1451410..1451717 + 308 Protein_1375 Arm DNA-binding domain-containing protein -
PQP99_RS07030 (1451697) 1451697..1452011 - 315 WP_023232245.1 hypothetical protein -
PQP99_RS07035 (1452172) 1452172..1452951 + 780 WP_023232244.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1448727..1449659 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T270458 WP_001199743.1 NZ_CP117312:1450667-1450975 [Salmonella enterica subsp. enterica serovar Derby]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT270458 WP_000016244.1 NZ_CP117312:1450425-1450664 [Salmonella enterica subsp. enterica serovar Derby]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References