Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1408291..1408934 Replicon chromosome
Accession NZ_CP117312
Organism Salmonella enterica subsp. enterica serovar Derby strain RM003

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag PQP99_RS06800 Protein ID WP_000048134.1
Coordinates 1408291..1408707 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PQP99_RS06805 Protein ID WP_001261294.1
Coordinates 1408704..1408934 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP99_RS06780 (1403328) 1403328..1404461 + 1134 WP_274879887.1 amidohydrolase/deacetylase family metallohydrolase -
PQP99_RS06785 (1404445) 1404445..1405563 + 1119 WP_023232259.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP99_RS06790 (1405560) 1405560..1406300 + 741 WP_023229489.1 KDGP aldolase family protein -
PQP99_RS06795 (1406317) 1406317..1408230 + 1914 WP_023232258.1 BglG family transcription antiterminator -
PQP99_RS06800 (1408291) 1408291..1408707 - 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
PQP99_RS06805 (1408704) 1408704..1408934 - 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQP99_RS06810 (1409101) 1409101..1409565 - 465 WP_023232257.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP99_RS06815 (1409686) 1409686..1411824 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP99_RS06820 (1412233) 1412233..1413885 - 1653 WP_023232256.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T270457 WP_000048134.1 NZ_CP117312:c1408707-1408291 [Salmonella enterica subsp. enterica serovar Derby]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT270457 WP_001261294.1 NZ_CP117312:c1408934-1408704 [Salmonella enterica subsp. enterica serovar Derby]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References