Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1257850..1258631 Replicon chromosome
Accession NZ_CP117312
Organism Salmonella enterica subsp. enterica serovar Derby strain RM003

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3Y7QYP9
Locus tag PQP99_RS06010 Protein ID WP_023231674.1
Coordinates 1258140..1258631 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3Y7QYQ5
Locus tag PQP99_RS06005 Protein ID WP_023231675.1
Coordinates 1257850..1258143 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP99_RS05970 (1254149) 1254149..1255054 + 906 WP_023231677.1 YjiK family protein -
PQP99_RS05975 (1255349) 1255349..1255483 - 135 Protein_1170 hypothetical protein -
PQP99_RS05980 (1255591) 1255591..1255690 - 100 Protein_1171 hypothetical protein -
PQP99_RS05985 (1255710) 1255710..1255892 + 183 WP_023231676.1 ATP-binding cassette domain-containing protein -
PQP99_RS05990 (1255885) 1255885..1256172 - 288 WP_001269916.1 transcriptional regulator RtsB -
PQP99_RS05995 (1256169) 1256169..1257044 - 876 WP_023195838.1 AraC family transcriptional regulator -
PQP99_RS06000 (1257310) 1257310..1257532 - 223 Protein_1175 hypothetical protein -
PQP99_RS06005 (1257850) 1257850..1258143 + 294 WP_023231675.1 DUF1778 domain-containing protein Antitoxin
PQP99_RS06010 (1258140) 1258140..1258631 + 492 WP_023231674.1 GNAT family N-acetyltransferase Toxin
PQP99_RS06015 (1258846) 1258846..1259094 + 249 Protein_1178 IS481 family transposase -
PQP99_RS06020 (1259375) 1259375..1259721 - 347 Protein_1179 Rpn family recombination-promoting nuclease/putative transposase -
PQP99_RS06025 (1259738) 1259738..1259881 - 144 Protein_1180 transposase -
PQP99_RS06030 (1260414) 1260414..1260719 + 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQP99_RS06035 (1260921) 1260921..1261751 + 831 WP_023231671.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17643.45 Da        Isoelectric Point: 7.2655

>T270456 WP_023231674.1 NZ_CP117312:1258140-1258631 [Salmonella enterica subsp. enterica serovar Derby]
MISPPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQATGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10930.60 Da        Isoelectric Point: 9.8590

>AT270456 WP_023231675.1 NZ_CP117312:1257850-1258143 [Salmonella enterica subsp. enterica serovar Derby]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPVPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y7QYP9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Y7QYQ5

References