Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 980306..981120 | Replicon | chromosome |
| Accession | NZ_CP117312 | ||
| Organism | Salmonella enterica subsp. enterica serovar Derby strain RM003 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3W0ARB0 |
| Locus tag | PQP99_RS04660 | Protein ID | WP_023231965.1 |
| Coordinates | 980306..980833 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PQP99_RS04665 | Protein ID | WP_000855694.1 |
| Coordinates | 980830..981120 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQP99_RS04640 (975518) | 975518..978085 | - | 2568 | WP_001005814.1 | DNA mismatch repair protein MutS | - |
| PQP99_RS04645 (978244) | 978244..978770 | + | 527 | Protein_909 | cytoplasmic protein | - |
| PQP99_RS04650 (979013) | 979013..979669 | - | 657 | WP_000420451.1 | protein-serine/threonine phosphatase | - |
| PQP99_RS04655 (980010) | 980010..980233 | + | 224 | Protein_911 | IS5/IS1182 family transposase | - |
| PQP99_RS04660 (980306) | 980306..980833 | - | 528 | WP_023231965.1 | GNAT family N-acetyltransferase | Toxin |
| PQP99_RS04665 (980830) | 980830..981120 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PQP99_RS04670 (981390) | 981390..981579 | - | 190 | Protein_914 | IS3 family transposase | - |
| PQP99_RS04675 (981984) | 981984..982427 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PQP99_RS04680 (982884) | 982884..983534 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
| PQP99_RS04685 (983531) | 983531..985219 | + | 1689 | WP_000848114.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 980093..988847 | 8754 | |
| - | flank | IS/Tn | - | - | 980093..980233 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19099.93 Da Isoelectric Point: 9.6420
>T270455 WP_023231965.1 NZ_CP117312:c980833-980306 [Salmonella enterica subsp. enterica serovar Derby]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT270455 WP_000855694.1 NZ_CP117312:c981120-980830 [Salmonella enterica subsp. enterica serovar Derby]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W0ARB0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |