Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4263684..4264465 Replicon chromosome
Accession NZ_CP117307
Organism Salmonella enterica subsp. enterica serovar Derby strain RM004

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3Y7QYP9
Locus tag PQQ01_RS20680 Protein ID WP_023231674.1
Coordinates 4263684..4264175 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3Y7QYQ5
Locus tag PQQ01_RS20685 Protein ID WP_023231675.1
Coordinates 4264172..4264465 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ01_RS20655 (4260564) 4260564..4261394 - 831 WP_023231671.1 fimbria/pilus periplasmic chaperone -
PQQ01_RS20660 (4261596) 4261596..4261901 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQQ01_RS20665 (4262434) 4262434..4262577 + 144 Protein_4042 transposase -
PQQ01_RS20670 (4262594) 4262594..4262940 + 347 Protein_4043 Rpn family recombination-promoting nuclease/putative transposase -
PQQ01_RS20675 (4263221) 4263221..4263469 - 249 Protein_4044 IS481 family transposase -
PQQ01_RS20680 (4263684) 4263684..4264175 - 492 WP_023231674.1 GNAT family N-acetyltransferase Toxin
PQQ01_RS20685 (4264172) 4264172..4264465 - 294 WP_023231675.1 DUF1778 domain-containing protein Antitoxin
PQQ01_RS20690 (4264783) 4264783..4265005 + 223 Protein_4047 hypothetical protein -
PQQ01_RS20695 (4265271) 4265271..4266146 + 876 WP_023195838.1 AraC family transcriptional regulator -
PQQ01_RS20700 (4266143) 4266143..4266430 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ01_RS20705 (4266423) 4266423..4266605 - 183 WP_023231676.1 ATP-binding cassette domain-containing protein -
PQQ01_RS20710 (4266625) 4266625..4266724 + 100 Protein_4051 hypothetical protein -
PQQ01_RS20715 (4266832) 4266832..4266966 + 135 Protein_4052 hypothetical protein -
PQQ01_RS20720 (4267261) 4267261..4268166 - 906 WP_023231677.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17643.45 Da        Isoelectric Point: 7.2655

>T270450 WP_023231674.1 NZ_CP117307:c4264175-4263684 [Salmonella enterica subsp. enterica serovar Derby]
MISPPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQATGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10930.60 Da        Isoelectric Point: 9.8590

>AT270450 WP_023231675.1 NZ_CP117307:c4264465-4264172 [Salmonella enterica subsp. enterica serovar Derby]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPVPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y7QYP9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Y7QYQ5

References