Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4113379..4114022 Replicon chromosome
Accession NZ_CP117307
Organism Salmonella enterica subsp. enterica serovar Derby strain RM004

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag PQQ01_RS19890 Protein ID WP_000048134.1
Coordinates 4113606..4114022 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PQQ01_RS19885 Protein ID WP_001261294.1
Coordinates 4113379..4113609 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ01_RS19870 (4108428) 4108428..4110080 + 1653 WP_023232256.1 alpha,alpha-phosphotrehalase -
PQQ01_RS19875 (4110489) 4110489..4112627 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ01_RS19880 (4112748) 4112748..4113212 + 465 WP_023232257.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ01_RS19885 (4113379) 4113379..4113609 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQQ01_RS19890 (4113606) 4113606..4114022 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
PQQ01_RS19895 (4114083) 4114083..4115996 - 1914 WP_023232258.1 BglG family transcription antiterminator -
PQQ01_RS19900 (4116013) 4116013..4116753 - 741 WP_023229489.1 KDGP aldolase family protein -
PQQ01_RS19905 (4116750) 4116750..4117868 - 1119 WP_023232259.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ01_RS19910 (4117852) 4117852..4118985 - 1134 WP_274890767.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T270449 WP_000048134.1 NZ_CP117307:4113606-4114022 [Salmonella enterica subsp. enterica serovar Derby]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT270449 WP_001261294.1 NZ_CP117307:4113379-4113609 [Salmonella enterica subsp. enterica serovar Derby]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References