Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4071338..4071888 Replicon chromosome
Accession NZ_CP117307
Organism Salmonella enterica subsp. enterica serovar Derby strain RM004

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag PQQ01_RS19670 Protein ID WP_001199743.1
Coordinates 4071338..4071646 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag PQQ01_RS19675 Protein ID WP_000016244.1
Coordinates 4071649..4071888 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ01_RS19655 (4069362) 4069362..4070141 - 780 WP_023232244.1 HNH endonuclease -
PQQ01_RS19660 (4070302) 4070302..4070616 + 315 WP_023232245.1 hypothetical protein -
PQQ01_RS19665 (4070596) 4070596..4070903 - 308 Protein_3847 Arm DNA-binding domain-containing protein -
PQQ01_RS19670 (4071338) 4071338..4071646 - 309 WP_001199743.1 CcdB family protein Toxin
PQQ01_RS19675 (4071649) 4071649..4071888 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PQQ01_RS19680 (4072001) 4072001..4072249 - 249 WP_000168385.1 ribbon-helix-helix domain-containing protein -
PQQ01_RS19685 (4072326) 4072326..4072634 - 309 Protein_3851 DUF4942 domain-containing protein -
PQQ01_RS19690 (4072654) 4072654..4073631 - 978 WP_223156438.1 IS630 family transposase -
PQQ01_RS19700 (4074389) 4074389..4075408 + 1020 WP_274890765.1 NAD(P)-dependent alcohol dehydrogenase -
PQQ01_RS19705 (4075436) 4075436..4075966 - 531 WP_023232248.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4072654..4073586 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T270448 WP_001199743.1 NZ_CP117307:c4071646-4071338 [Salmonella enterica subsp. enterica serovar Derby]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT270448 WP_000016244.1 NZ_CP117307:c4071888-4071649 [Salmonella enterica subsp. enterica serovar Derby]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References