Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3380412..3381032 Replicon chromosome
Accession NZ_CP117307
Organism Salmonella enterica subsp. enterica serovar Derby strain RM004

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ01_RS16380 Protein ID WP_001280991.1
Coordinates 3380814..3381032 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q7HJ94
Locus tag PQQ01_RS16375 Protein ID WP_023231707.1
Coordinates 3380412..3380786 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ01_RS16365 (3375551) 3375551..3376744 + 1194 WP_023231706.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ01_RS16370 (3376767) 3376767..3379916 + 3150 WP_274890715.1 efflux RND transporter permease AcrB -
PQQ01_RS16375 (3380412) 3380412..3380786 + 375 WP_023231707.1 Hha toxicity modulator TomB Antitoxin
PQQ01_RS16380 (3380814) 3380814..3381032 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ01_RS16385 (3381211) 3381211..3381762 + 552 WP_274890716.1 maltose O-acetyltransferase -
PQQ01_RS16390 (3381880) 3381880..3382350 + 471 WP_000136183.1 YlaC family protein -
PQQ01_RS16395 (3382406) 3382406..3382546 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ01_RS16400 (3382552) 3382552..3382812 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ01_RS16405 (3383037) 3383037..3384587 + 1551 WP_274890717.1 EAL domain-containing protein -
PQQ01_RS16415 (3384818) 3384818..3385207 + 390 WP_000961285.1 MGMT family protein -
PQQ01_RS16420 (3385240) 3385240..3385809 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270445 WP_001280991.1 NZ_CP117307:3380814-3381032 [Salmonella enterica subsp. enterica serovar Derby]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14439.24 Da        Isoelectric Point: 5.1444

>AT270445 WP_023231707.1 NZ_CP117307:3380412-3380786 [Salmonella enterica subsp. enterica serovar Derby]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q7HJ94

References