270440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2312419..2312941 Replicon chromosome
Accession NZ_CP117307
Organism Salmonella enterica subsp. enterica serovar Derby strain RM004

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQQ01_RS11200 Protein ID WP_000221343.1
Coordinates 2312419..2312703 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQQ01_RS11205 Protein ID WP_000885424.1
Coordinates 2312693..2312941 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ01_RS11180 (2308494) 2308494..2310002 - 1509 WP_048348841.1 FAD-dependent oxidoreductase -
PQQ01_RS11185 (2310047) 2310047..2310535 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQQ01_RS11190 (2310728) 2310728..2311807 + 1080 WP_023231841.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQQ01_RS11195 (2311859) 2311859..2312248 - 390 WP_023206403.1 RidA family protein -
PQQ01_RS11200 (2312419) 2312419..2312703 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ01_RS11205 (2312693) 2312693..2312941 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ01_RS11210 (2313616) 2313616..2314038 + 423 WP_048348840.1 PTS sugar transporter subunit IIA -
PQQ01_RS11215 (2314098) 2314098..2314379 + 282 WP_023218025.1 PTS sugar transporter subunit IIB -
PQQ01_RS11220 (2314391) 2314391..2315782 + 1392 WP_274891007.1 PTS galactitol transporter subunit IIC -
PQQ01_RS11225 (2315860) 2315860..2317371 + 1512 WP_023231843.1 FGGY family carbohydrate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2310728..2327841 17113


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270440 WP_000221343.1 NZ_CP117307:c2312703-2312419 [Salmonella enterica subsp. enterica serovar Derby]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270440 WP_000885424.1 NZ_CP117307:c2312941-2312693 [Salmonella enterica subsp. enterica serovar Derby]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References