Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 980040..980854 | Replicon | chromosome |
| Accession | NZ_CP117307 | ||
| Organism | Salmonella enterica subsp. enterica serovar Derby strain RM004 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3W0ARB0 |
| Locus tag | PQQ01_RS04665 | Protein ID | WP_023231965.1 |
| Coordinates | 980040..980567 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PQQ01_RS04670 | Protein ID | WP_000855694.1 |
| Coordinates | 980564..980854 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQQ01_RS04645 (975252) | 975252..977819 | - | 2568 | WP_001005814.1 | DNA mismatch repair protein MutS | - |
| PQQ01_RS04650 (977978) | 977978..978504 | + | 527 | Protein_910 | cytoplasmic protein | - |
| PQQ01_RS04655 (978747) | 978747..979403 | - | 657 | WP_000420451.1 | protein-serine/threonine phosphatase | - |
| PQQ01_RS04660 (979744) | 979744..979967 | + | 224 | Protein_912 | IS5/IS1182 family transposase | - |
| PQQ01_RS04665 (980040) | 980040..980567 | - | 528 | WP_023231965.1 | GNAT family N-acetyltransferase | Toxin |
| PQQ01_RS04670 (980564) | 980564..980854 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PQQ01_RS04675 (981124) | 981124..981313 | - | 190 | Protein_915 | IS3 family transposase | - |
| PQQ01_RS04680 (981718) | 981718..982161 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PQQ01_RS04685 (982618) | 982618..983268 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
| PQQ01_RS04690 (983265) | 983265..984953 | + | 1689 | WP_000848114.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 979827..988581 | 8754 | |
| - | flank | IS/Tn | - | - | 979827..979967 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19099.93 Da Isoelectric Point: 9.6420
>T270439 WP_023231965.1 NZ_CP117307:c980567-980040 [Salmonella enterica subsp. enterica serovar Derby]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT270439 WP_000855694.1 NZ_CP117307:c980854-980564 [Salmonella enterica subsp. enterica serovar Derby]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W0ARB0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |