Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 815870..816530 Replicon chromosome
Accession NZ_CP117307
Organism Salmonella enterica subsp. enterica serovar Derby strain RM004

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQQ01_RS03920 Protein ID WP_000244756.1
Coordinates 816117..816530 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQQ01_RS03915 Protein ID WP_000351186.1
Coordinates 815870..816136 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ01_RS03895 (811799) 811799..813232 - 1434 WP_023232670.1 6-phospho-beta-glucosidase BglA -
PQQ01_RS03900 (813390) 813390..813701 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQQ01_RS03905 (813865) 813865..814524 + 660 WP_000250289.1 hemolysin III family protein -
PQQ01_RS03910 (814640) 814640..815620 - 981 WP_023232672.1 tRNA-modifying protein YgfZ -
PQQ01_RS03915 (815870) 815870..816136 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQQ01_RS03920 (816117) 816117..816530 + 414 WP_000244756.1 protein YgfX Toxin
PQQ01_RS03925 (816583) 816583..817104 - 522 WP_001055885.1 flavodoxin FldB -
PQQ01_RS03930 (817217) 817217..818113 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQQ01_RS03935 (818137) 818137..818850 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ01_RS03940 (818856) 818856..820589 + 1734 WP_274890887.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270438 WP_000244756.1 NZ_CP117307:816117-816530 [Salmonella enterica subsp. enterica serovar Derby]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270438 WP_000351186.1 NZ_CP117307:815870-816136 [Salmonella enterica subsp. enterica serovar Derby]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References