Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4276405..4277186 Replicon chromosome
Accession NZ_CP117305
Organism Salmonella enterica subsp. enterica serovar Derby strain RM005

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3Y7QYP9
Locus tag PQP92_RS20750 Protein ID WP_023231674.1
Coordinates 4276405..4276896 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3Y7QYQ5
Locus tag PQP92_RS20755 Protein ID WP_023231675.1
Coordinates 4276893..4277186 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP92_RS20725 (4273285) 4273285..4274115 - 831 WP_023231671.1 fimbria/pilus periplasmic chaperone -
PQP92_RS20730 (4274317) 4274317..4274622 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQP92_RS20735 (4275155) 4275155..4275298 + 144 Protein_4056 transposase -
PQP92_RS20740 (4275315) 4275315..4275661 + 347 Protein_4057 Rpn family recombination-promoting nuclease/putative transposase -
PQP92_RS20745 (4275942) 4275942..4276190 - 249 Protein_4058 IS481 family transposase -
PQP92_RS20750 (4276405) 4276405..4276896 - 492 WP_023231674.1 GNAT family N-acetyltransferase Toxin
PQP92_RS20755 (4276893) 4276893..4277186 - 294 WP_023231675.1 DUF1778 domain-containing protein Antitoxin
PQP92_RS20760 (4277504) 4277504..4277726 + 223 Protein_4061 hypothetical protein -
PQP92_RS20765 (4277992) 4277992..4278867 + 876 WP_023195838.1 AraC family transcriptional regulator -
PQP92_RS20770 (4278864) 4278864..4279151 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP92_RS20775 (4279144) 4279144..4279326 - 183 WP_023231676.1 ATP-binding cassette domain-containing protein -
PQP92_RS20780 (4279346) 4279346..4279445 + 100 Protein_4065 hypothetical protein -
PQP92_RS20785 (4279553) 4279553..4279687 + 135 Protein_4066 hypothetical protein -
PQP92_RS20790 (4279982) 4279982..4280887 - 906 WP_023231677.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17643.45 Da        Isoelectric Point: 7.2655

>T270434 WP_023231674.1 NZ_CP117305:c4276896-4276405 [Salmonella enterica subsp. enterica serovar Derby]
MISPPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQATGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10930.60 Da        Isoelectric Point: 9.8590

>AT270434 WP_023231675.1 NZ_CP117305:c4277186-4276893 [Salmonella enterica subsp. enterica serovar Derby]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPVPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y7QYP9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Y7QYQ5

References