Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4126101..4126744 Replicon chromosome
Accession NZ_CP117305
Organism Salmonella enterica subsp. enterica serovar Derby strain RM005

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag PQP92_RS19960 Protein ID WP_000048134.1
Coordinates 4126328..4126744 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PQP92_RS19955 Protein ID WP_001261294.1
Coordinates 4126101..4126331 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP92_RS19940 (4121150) 4121150..4122802 + 1653 WP_023232256.1 alpha,alpha-phosphotrehalase -
PQP92_RS19945 (4123211) 4123211..4125349 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP92_RS19950 (4125470) 4125470..4125934 + 465 WP_023232257.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP92_RS19955 (4126101) 4126101..4126331 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQP92_RS19960 (4126328) 4126328..4126744 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
PQP92_RS19965 (4126805) 4126805..4128718 - 1914 WP_023232258.1 BglG family transcription antiterminator -
PQP92_RS19970 (4128735) 4128735..4129475 - 741 WP_023229489.1 KDGP aldolase family protein -
PQP92_RS19975 (4129472) 4129472..4130590 - 1119 WP_023232259.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP92_RS19980 (4130574) 4130574..4131707 - 1134 WP_023232260.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T270433 WP_000048134.1 NZ_CP117305:4126328-4126744 [Salmonella enterica subsp. enterica serovar Derby]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT270433 WP_001261294.1 NZ_CP117305:4126101-4126331 [Salmonella enterica subsp. enterica serovar Derby]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References