Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4084060..4084610 Replicon chromosome
Accession NZ_CP117305
Organism Salmonella enterica subsp. enterica serovar Derby strain RM005

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag PQP92_RS19740 Protein ID WP_001199743.1
Coordinates 4084060..4084368 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag PQP92_RS19745 Protein ID WP_000016244.1
Coordinates 4084371..4084610 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP92_RS19725 (4082084) 4082084..4082863 - 780 WP_023232244.1 HNH endonuclease -
PQP92_RS19730 (4083024) 4083024..4083338 + 315 WP_023232245.1 hypothetical protein -
PQP92_RS19735 (4083318) 4083318..4083625 - 308 Protein_3861 Arm DNA-binding domain-containing protein -
PQP92_RS19740 (4084060) 4084060..4084368 - 309 WP_001199743.1 CcdB family protein Toxin
PQP92_RS19745 (4084371) 4084371..4084610 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PQP92_RS19750 (4084723) 4084723..4084971 - 249 WP_000168385.1 ribbon-helix-helix domain-containing protein -
PQP92_RS19755 (4085048) 4085048..4085356 - 309 Protein_3865 DUF4942 domain-containing protein -
PQP92_RS19760 (4085376) 4085376..4086353 - 978 WP_223156438.1 IS630 family transposase -
PQP92_RS19770 (4087111) 4087111..4088130 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
PQP92_RS19775 (4088158) 4088158..4088688 - 531 WP_023232248.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4085376..4086308 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T270432 WP_001199743.1 NZ_CP117305:c4084368-4084060 [Salmonella enterica subsp. enterica serovar Derby]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT270432 WP_000016244.1 NZ_CP117305:c4084610-4084371 [Salmonella enterica subsp. enterica serovar Derby]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References