Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3393122..3393742 Replicon chromosome
Accession NZ_CP117305
Organism Salmonella enterica subsp. enterica serovar Derby strain RM005

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP92_RS16450 Protein ID WP_001280991.1
Coordinates 3393524..3393742 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q7HJ94
Locus tag PQP92_RS16445 Protein ID WP_023231707.1
Coordinates 3393122..3393496 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP92_RS16435 (3388261) 3388261..3389454 + 1194 WP_023231706.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP92_RS16440 (3389477) 3389477..3392626 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP92_RS16445 (3393122) 3393122..3393496 + 375 WP_023231707.1 Hha toxicity modulator TomB Antitoxin
PQP92_RS16450 (3393524) 3393524..3393742 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP92_RS16455 (3393921) 3393921..3394472 + 552 WP_001278793.1 maltose O-acetyltransferase -
PQP92_RS16460 (3394590) 3394590..3395060 + 471 WP_000136183.1 YlaC family protein -
PQP92_RS16465 (3395116) 3395116..3395256 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP92_RS16470 (3395262) 3395262..3395522 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP92_RS16475 (3395747) 3395747..3397297 + 1551 WP_023231708.1 EAL domain-containing protein -
PQP92_RS16485 (3397528) 3397528..3397917 + 390 WP_000961285.1 MGMT family protein -
PQP92_RS16490 (3397950) 3397950..3398519 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270429 WP_001280991.1 NZ_CP117305:3393524-3393742 [Salmonella enterica subsp. enterica serovar Derby]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14439.24 Da        Isoelectric Point: 5.1444

>AT270429 WP_023231707.1 NZ_CP117305:3393122-3393496 [Salmonella enterica subsp. enterica serovar Derby]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q7HJ94

References