270424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2325021..2325543 Replicon chromosome
Accession NZ_CP117305
Organism Salmonella enterica subsp. enterica serovar Derby strain RM005

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQP92_RS11270 Protein ID WP_000221343.1
Coordinates 2325021..2325305 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP92_RS11275 Protein ID WP_000885424.1
Coordinates 2325295..2325543 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP92_RS11250 (2321096) 2321096..2322604 - 1509 WP_048348841.1 FAD-dependent oxidoreductase -
PQP92_RS11255 (2322649) 2322649..2323137 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP92_RS11260 (2323330) 2323330..2324409 + 1080 WP_023231841.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP92_RS11265 (2324461) 2324461..2324850 - 390 WP_023206403.1 RidA family protein -
PQP92_RS11270 (2325021) 2325021..2325305 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP92_RS11275 (2325295) 2325295..2325543 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP92_RS11280 (2326218) 2326218..2326640 + 423 WP_048348840.1 PTS sugar transporter subunit IIA -
PQP92_RS11285 (2326700) 2326700..2326981 + 282 WP_023218025.1 PTS sugar transporter subunit IIB -
PQP92_RS11290 (2326993) 2326993..2328384 + 1392 WP_023218026.1 PTS galactitol transporter subunit IIC -
PQP92_RS11295 (2328461) 2328461..2329972 + 1512 WP_023231843.1 FGGY family carbohydrate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2323330..2340442 17112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270424 WP_000221343.1 NZ_CP117305:c2325305-2325021 [Salmonella enterica subsp. enterica serovar Derby]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270424 WP_000885424.1 NZ_CP117305:c2325543-2325295 [Salmonella enterica subsp. enterica serovar Derby]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References