Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 816114..816774 Replicon chromosome
Accession NZ_CP117305
Organism Salmonella enterica subsp. enterica serovar Derby strain RM005

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQP92_RS03910 Protein ID WP_000244756.1
Coordinates 816361..816774 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQP92_RS03905 Protein ID WP_000351186.1
Coordinates 816114..816380 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP92_RS03885 (812043) 812043..813476 - 1434 WP_023232670.1 6-phospho-beta-glucosidase BglA -
PQP92_RS03890 (813634) 813634..813945 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQP92_RS03895 (814109) 814109..814768 + 660 WP_000250289.1 hemolysin III family protein -
PQP92_RS03900 (814884) 814884..815864 - 981 WP_023232672.1 tRNA-modifying protein YgfZ -
PQP92_RS03905 (816114) 816114..816380 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQP92_RS03910 (816361) 816361..816774 + 414 WP_000244756.1 protein YgfX Toxin
PQP92_RS03915 (816827) 816827..817348 - 522 WP_001055885.1 flavodoxin FldB -
PQP92_RS03920 (817461) 817461..818357 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQP92_RS03925 (818381) 818381..819094 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP92_RS03930 (819100) 819100..820833 + 1734 WP_023181521.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270422 WP_000244756.1 NZ_CP117305:816361-816774 [Salmonella enterica subsp. enterica serovar Derby]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270422 WP_000351186.1 NZ_CP117305:816114-816380 [Salmonella enterica subsp. enterica serovar Derby]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References