Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4256097..4256878 Replicon chromosome
Accession NZ_CP117301
Organism Salmonella enterica subsp. enterica serovar Derby strain RM006

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3Y7QYP9
Locus tag PQP83_RS20610 Protein ID WP_023231674.1
Coordinates 4256097..4256588 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3Y7QYQ5
Locus tag PQP83_RS20615 Protein ID WP_023231675.1
Coordinates 4256585..4256878 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP83_RS20585 (4252977) 4252977..4253807 - 831 WP_023231671.1 fimbria/pilus periplasmic chaperone -
PQP83_RS20590 (4254009) 4254009..4254314 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQP83_RS20595 (4254847) 4254847..4254990 + 144 Protein_4028 transposase -
PQP83_RS20600 (4255007) 4255007..4255353 + 347 Protein_4029 Rpn family recombination-promoting nuclease/putative transposase -
PQP83_RS20605 (4255634) 4255634..4255882 - 249 Protein_4030 IS481 family transposase -
PQP83_RS20610 (4256097) 4256097..4256588 - 492 WP_023231674.1 GNAT family N-acetyltransferase Toxin
PQP83_RS20615 (4256585) 4256585..4256878 - 294 WP_023231675.1 DUF1778 domain-containing protein Antitoxin
PQP83_RS20620 (4257196) 4257196..4257418 + 223 Protein_4033 hypothetical protein -
PQP83_RS20625 (4257684) 4257684..4258559 + 876 WP_023195838.1 AraC family transcriptional regulator -
PQP83_RS20630 (4258556) 4258556..4258843 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP83_RS20635 (4258836) 4258836..4259018 - 183 WP_023231676.1 ATP-binding cassette domain-containing protein -
PQP83_RS20640 (4259038) 4259038..4259137 + 100 Protein_4037 hypothetical protein -
PQP83_RS20645 (4259245) 4259245..4259379 + 135 Protein_4038 hypothetical protein -
PQP83_RS20650 (4259674) 4259674..4260579 - 906 WP_023231677.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17643.45 Da        Isoelectric Point: 7.2655

>T270419 WP_023231674.1 NZ_CP117301:c4256588-4256097 [Salmonella enterica subsp. enterica serovar Derby]
MISPPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQATGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10930.60 Da        Isoelectric Point: 9.8590

>AT270419 WP_023231675.1 NZ_CP117301:c4256878-4256585 [Salmonella enterica subsp. enterica serovar Derby]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPVPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y7QYP9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Y7QYQ5

References