Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4105794..4106437 Replicon chromosome
Accession NZ_CP117301
Organism Salmonella enterica subsp. enterica serovar Derby strain RM006

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag PQP83_RS19820 Protein ID WP_000048134.1
Coordinates 4106021..4106437 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PQP83_RS19815 Protein ID WP_001261294.1
Coordinates 4105794..4106024 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP83_RS19800 (4100843) 4100843..4102495 + 1653 WP_023232256.1 alpha,alpha-phosphotrehalase -
PQP83_RS19805 (4102904) 4102904..4105042 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP83_RS19810 (4105163) 4105163..4105627 + 465 WP_023232257.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP83_RS19815 (4105794) 4105794..4106024 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQP83_RS19820 (4106021) 4106021..4106437 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
PQP83_RS19825 (4106498) 4106498..4108411 - 1914 WP_274881225.1 BglG family transcription antiterminator -
PQP83_RS19830 (4108428) 4108428..4109168 - 741 WP_023229489.1 KDGP aldolase family protein -
PQP83_RS19835 (4109165) 4109165..4110283 - 1119 WP_023232259.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP83_RS19840 (4110267) 4110267..4111400 - 1134 WP_274896384.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T270418 WP_000048134.1 NZ_CP117301:4106021-4106437 [Salmonella enterica subsp. enterica serovar Derby]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT270418 WP_001261294.1 NZ_CP117301:4105794-4106024 [Salmonella enterica subsp. enterica serovar Derby]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References