Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4063753..4064303 Replicon chromosome
Accession NZ_CP117301
Organism Salmonella enterica subsp. enterica serovar Derby strain RM006

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag PQP83_RS19600 Protein ID WP_001199743.1
Coordinates 4063753..4064061 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag PQP83_RS19605 Protein ID WP_000016244.1
Coordinates 4064064..4064303 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP83_RS19585 (4061777) 4061777..4062556 - 780 WP_023232244.1 HNH endonuclease -
PQP83_RS19590 (4062717) 4062717..4063031 + 315 WP_023232245.1 hypothetical protein -
PQP83_RS19595 (4063011) 4063011..4063318 - 308 Protein_3833 Arm DNA-binding domain-containing protein -
PQP83_RS19600 (4063753) 4063753..4064061 - 309 WP_001199743.1 CcdB family protein Toxin
PQP83_RS19605 (4064064) 4064064..4064303 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PQP83_RS19610 (4064416) 4064416..4064664 - 249 WP_000168385.1 ribbon-helix-helix domain-containing protein -
PQP83_RS19615 (4064741) 4064741..4065049 - 309 Protein_3837 DUF4942 domain-containing protein -
PQP83_RS19620 (4065069) 4065069..4066046 - 978 WP_223156438.1 IS630 family transposase -
PQP83_RS19630 (4066804) 4066804..4067823 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
PQP83_RS19635 (4067851) 4067851..4068381 - 531 Protein_3840 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4065069..4066001 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T270417 WP_001199743.1 NZ_CP117301:c4064061-4063753 [Salmonella enterica subsp. enterica serovar Derby]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT270417 WP_000016244.1 NZ_CP117301:c4064303-4064064 [Salmonella enterica subsp. enterica serovar Derby]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References