270414

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2364524..2365046 Replicon chromosome
Accession NZ_CP117301
Organism Salmonella enterica subsp. enterica serovar Derby strain RM006

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQP83_RS11415 Protein ID WP_000221343.1
Coordinates 2364762..2365046 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP83_RS11410 Protein ID WP_000885424.1
Coordinates 2364524..2364772 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP83_RS11390 (2360094) 2360094..2361605 - 1512 WP_023231843.1 FGGY family carbohydrate kinase -
PQP83_RS11395 (2361683) 2361683..2363074 - 1392 WP_274896569.1 PTS galactitol transporter subunit IIC -
PQP83_RS11400 (2363086) 2363086..2363367 - 282 WP_023218025.1 PTS sugar transporter subunit IIB -
PQP83_RS11405 (2363427) 2363427..2363849 - 423 WP_048348840.1 PTS sugar transporter subunit IIA -
PQP83_RS11410 (2364524) 2364524..2364772 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP83_RS11415 (2364762) 2364762..2365046 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP83_RS11420 (2365217) 2365217..2365606 + 390 WP_023206403.1 RidA family protein -
PQP83_RS11425 (2365658) 2365658..2366737 - 1080 WP_023231841.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP83_RS11430 (2366930) 2366930..2367418 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP83_RS11435 (2367463) 2367463..2368971 + 1509 WP_048348841.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2349624..2371828 22204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270414 WP_000221343.1 NZ_CP117301:2364762-2365046 [Salmonella enterica subsp. enterica serovar Derby]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270414 WP_000885424.1 NZ_CP117301:2364524-2364772 [Salmonella enterica subsp. enterica serovar Derby]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References