Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1296322..1296942 Replicon chromosome
Accession NZ_CP117301
Organism Salmonella enterica subsp. enterica serovar Derby strain RM006

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP83_RS06235 Protein ID WP_001280991.1
Coordinates 1296322..1296540 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q7HJ94
Locus tag PQP83_RS06240 Protein ID WP_023231707.1
Coordinates 1296568..1296942 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP83_RS06195 (1291545) 1291545..1292114 + 570 WP_000779802.1 YbaY family lipoprotein -
PQP83_RS06200 (1292147) 1292147..1292536 - 390 WP_000961285.1 MGMT family protein -
PQP83_RS06210 (1292767) 1292767..1294317 - 1551 WP_023231708.1 EAL domain-containing protein -
PQP83_RS06215 (1294542) 1294542..1294802 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP83_RS06220 (1294808) 1294808..1294948 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP83_RS06225 (1295004) 1295004..1295474 - 471 WP_000136183.1 YlaC family protein -
PQP83_RS06230 (1295592) 1295592..1296143 - 552 WP_274896512.1 maltose O-acetyltransferase -
PQP83_RS06235 (1296322) 1296322..1296540 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP83_RS06240 (1296568) 1296568..1296942 - 375 WP_023231707.1 Hha toxicity modulator TomB Antitoxin
PQP83_RS06245 (1297438) 1297438..1300587 - 3150 WP_274896513.1 efflux RND transporter permease AcrB -
PQP83_RS06250 (1300610) 1300610..1301803 - 1194 WP_023231706.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270409 WP_001280991.1 NZ_CP117301:c1296540-1296322 [Salmonella enterica subsp. enterica serovar Derby]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14439.24 Da        Isoelectric Point: 5.1444

>AT270409 WP_023231707.1 NZ_CP117301:c1296942-1296568 [Salmonella enterica subsp. enterica serovar Derby]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q7HJ94

References