Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 980307..981121 | Replicon | chromosome |
| Accession | NZ_CP117301 | ||
| Organism | Salmonella enterica subsp. enterica serovar Derby strain RM006 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3W0ARB0 |
| Locus tag | PQP83_RS04655 | Protein ID | WP_023231965.1 |
| Coordinates | 980307..980834 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PQP83_RS04660 | Protein ID | WP_000855694.1 |
| Coordinates | 980831..981121 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQP83_RS04635 (975519) | 975519..978086 | - | 2568 | WP_001005814.1 | DNA mismatch repair protein MutS | - |
| PQP83_RS04640 (978245) | 978245..978771 | + | 527 | Protein_908 | cytoplasmic protein | - |
| PQP83_RS04645 (979014) | 979014..979670 | - | 657 | WP_000420451.1 | protein-serine/threonine phosphatase | - |
| PQP83_RS04650 (980011) | 980011..980234 | + | 224 | Protein_910 | IS5/IS1182 family transposase | - |
| PQP83_RS04655 (980307) | 980307..980834 | - | 528 | WP_023231965.1 | GNAT family N-acetyltransferase | Toxin |
| PQP83_RS04660 (980831) | 980831..981121 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PQP83_RS04665 (981391) | 981391..981580 | - | 190 | Protein_913 | IS3 family transposase | - |
| PQP83_RS04670 (981985) | 981985..982428 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PQP83_RS04675 (982885) | 982885..983535 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
| PQP83_RS04680 (983532) | 983532..985220 | + | 1689 | WP_000848114.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 980094..988848 | 8754 | |
| - | flank | IS/Tn | - | - | 980094..980234 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19099.93 Da Isoelectric Point: 9.6420
>T270408 WP_023231965.1 NZ_CP117301:c980834-980307 [Salmonella enterica subsp. enterica serovar Derby]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT270408 WP_000855694.1 NZ_CP117301:c981121-980831 [Salmonella enterica subsp. enterica serovar Derby]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W0ARB0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |