270404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5639783..5640369 Replicon chromosome
Accession NZ_CP117300
Organism Pseudomonas aeruginosa strain 0201761-1

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PSH15_RS26820 Protein ID WP_003120987.1
Coordinates 5640070..5640369 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PSH15_RS26815 Protein ID WP_003448662.1
Coordinates 5639783..5640073 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSH15_RS26795 (PSH15_26795) 5635658..5636473 - 816 WP_023082672.1 ABC transporter permease -
PSH15_RS26800 (PSH15_26800) 5636815..5637519 - 705 WP_124082403.1 hypothetical protein -
PSH15_RS26805 (PSH15_26805) 5637613..5637957 + 345 WP_023082674.1 hypothetical protein -
PSH15_RS26810 (PSH15_26810) 5638097..5639368 + 1272 WP_023082545.1 IS4-like element ISPa1635 family transposase -
PSH15_RS26815 (PSH15_26815) 5639783..5640073 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PSH15_RS26820 (PSH15_26820) 5640070..5640369 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PSH15_RS26825 (PSH15_26825) 5640571..5641692 + 1122 WP_003448658.1 TcpQ domain-containing protein -
PSH15_RS26830 (PSH15_26830) 5641692..5643401 + 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
PSH15_RS26835 (PSH15_26835) 5643405..5644730 + 1326 WP_003120992.1 type 4b pilus protein PilO2 -
PSH15_RS26840 (PSH15_26840) 5644720..5645253 + 534 WP_003120993.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5579259..5696838 117579
- flank IS/Tn - - 5638097..5639368 1271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T270404 WP_003120987.1 NZ_CP117300:c5640369-5640070 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT270404 WP_003448662.1 NZ_CP117300:c5640073-5639783 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References