Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4831063..4832321 Replicon chromosome
Accession NZ_CP117300
Organism Pseudomonas aeruginosa strain 0201761-1

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PSH15_RS22915 Protein ID WP_003112528.1
Coordinates 4831063..4831818 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PSH15_RS22920 Protein ID WP_003086329.1
Coordinates 4831953..4832321 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSH15_RS22905 (PSH15_22905) 4826234..4828777 + 2544 WP_003120631.1 acyl-homoserine-lactone acylase QuiP -
PSH15_RS22910 (PSH15_22910) 4828933..4830294 - 1362 WP_003120632.1 DNA recombination protein RmuC -
PSH15_RS22915 (PSH15_22915) 4831063..4831818 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PSH15_RS22920 (PSH15_22920) 4831953..4832321 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PSH15_RS22925 (PSH15_22925) 4832394..4833680 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
PSH15_RS22930 (PSH15_22930) 4833736..4835229 - 1494 WP_023093552.1 aldehyde dehydrogenase family protein -
PSH15_RS22935 (PSH15_22935) 4835404..4835880 + 477 WP_003112531.1 hypothetical protein -
PSH15_RS22940 (PSH15_22940) 4835883..4836158 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T270403 WP_003112528.1 NZ_CP117300:c4831818-4831063 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT270403 WP_003086329.1 NZ_CP117300:c4832321-4831953 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References