270402

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4194071..4195113 Replicon chromosome
Accession NZ_CP117300
Organism Pseudomonas aeruginosa strain 0201761-1

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PSH15_RS19855 Protein ID WP_003109777.1
Coordinates 4194071..4194646 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PSH15_RS19860 Protein ID WP_003050245.1
Coordinates 4194643..4195113 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSH15_RS19830 (PSH15_19830) 4190509..4191234 - 726 WP_003120003.1 CBASS effector endonuclease NucC -
PSH15_RS19835 (PSH15_19835) 4191273..4192175 - 903 WP_003105624.1 CBASS oligonucleotide cyclase -
PSH15_RS19840 (PSH15_19840) 4192175..4192675 - 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PSH15_RS19845 (PSH15_19845) 4192672..4193142 - 471 WP_003105626.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PSH15_RS19850 (PSH15_19850) 4193139..4194053 - 915 WP_003120002.1 AAA family ATPase -
PSH15_RS19855 (PSH15_19855) 4194071..4194646 - 576 WP_003109777.1 PIN domain-containing protein Toxin
PSH15_RS19860 (PSH15_19860) 4194643..4195113 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PSH15_RS19865 (PSH15_19865) 4195317..4195700 + 384 WP_003120001.1 RAQPRD family integrative conjugative element protein -
PSH15_RS19870 (PSH15_19870) 4195697..4195930 + 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
PSH15_RS19875 (PSH15_19875) 4195947..4196306 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PSH15_RS19880 (PSH15_19880) 4196318..4196716 + 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PSH15_RS19885 (PSH15_19885) 4196713..4197405 + 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PSH15_RS19890 (PSH15_19890) 4197402..4198313 + 912 WP_010791730.1 TIGR03749 family integrating conjugative element protein -
PSH15_RS19895 (PSH15_19895) 4198303..4199721 + 1419 WP_003119999.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4187877..4196716 8839


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T270402 WP_003109777.1 NZ_CP117300:c4194646-4194071 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT270402 WP_003050245.1 NZ_CP117300:c4195113-4194643 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References