Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 2919762..2920982 | Replicon | chromosome |
| Accession | NZ_CP117300 | ||
| Organism | Pseudomonas aeruginosa strain 0201761-1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PSH15_RS13965 | Protein ID | WP_003118970.1 |
| Coordinates | 2919762..2920340 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PSH15_RS13970 | Protein ID | WP_003088112.1 |
| Coordinates | 2920428..2920982 (-) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PSH15_RS13950 (PSH15_13950) | 2915039..2916316 | + | 1278 | WP_003102743.1 | TolC family protein | - |
| PSH15_RS13955 (PSH15_13955) | 2916306..2918477 | + | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| PSH15_RS13960 (PSH15_13960) | 2918467..2919654 | + | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PSH15_RS13965 (PSH15_13965) | 2919762..2920340 | - | 579 | WP_003118970.1 | HD domain-containing protein | Toxin |
| PSH15_RS13970 (PSH15_13970) | 2920428..2920982 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PSH15_RS13975 (PSH15_13975) | 2921140..2923335 | - | 2196 | WP_003118969.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PSH15_RS13980 (PSH15_13980) | 2923340..2923801 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PSH15_RS13985 (PSH15_13985) | 2924132..2924455 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PSH15_RS13990 (PSH15_13990) | 2924468..2924866 | + | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| PSH15_RS13995 (PSH15_13995) | 2924863..2925414 | - | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21899.72 Da Isoelectric Point: 5.3655
>T270401 WP_003118970.1 NZ_CP117300:c2920340-2919762 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT270401 WP_003088112.1 NZ_CP117300:c2920982-2920428 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|