Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150412..150917 Replicon chromosome
Accession NZ_CP117300
Organism Pseudomonas aeruginosa strain 0201761-1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PSH15_RS00685 Protein ID WP_003083773.1
Coordinates 150412..150693 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PSH15_RS00690 Protein ID WP_003083775.1
Coordinates 150690..150917 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSH15_RS00660 (PSH15_00660) 145663..147012 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PSH15_RS00665 (PSH15_00665) 147061..147747 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PSH15_RS00670 (PSH15_00670) 147848..148582 + 735 WP_003117208.1 GntR family transcriptional regulator -
PSH15_RS00675 (PSH15_00675) 148762..149172 + 411 WP_003101225.1 aegerolysin family protein -
PSH15_RS00680 (PSH15_00680) 149204..150112 - 909 WP_003083769.1 LysR family transcriptional regulator -
PSH15_RS00685 (PSH15_00685) 150412..150693 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PSH15_RS00690 (PSH15_00690) 150690..150917 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PSH15_RS00695 (PSH15_00695) 151093..151713 - 621 WP_003101226.1 hypothetical protein -
PSH15_RS00700 (PSH15_00700) 151814..152314 + 501 WP_003101228.1 LEA type 2 family protein -
PSH15_RS00705 (PSH15_00705) 152387..152728 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PSH15_RS00710 (PSH15_00710) 152810..154237 - 1428 WP_003083784.1 GABA permease -
PSH15_RS00715 (PSH15_00715) 154406..155899 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T270399 WP_003083773.1 NZ_CP117300:c150693-150412 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT270399 WP_003083775.1 NZ_CP117300:c150917-150690 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References