Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4704607..4705398 Replicon chromosome
Accession NZ_CP117299
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag PH350_RS23025 Protein ID WP_000369560.1
Coordinates 4704607..4705125 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag PH350_RS23030 Protein ID WP_001275017.1
Coordinates 4705129..4705398 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH350_RS23000 (4699672) 4699672..4700439 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PH350_RS23005 (4700436) 4700436..4701713 - 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
PH350_RS23010 (4701710) 4701710..4702636 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PH350_RS23015 (4702696) 4702696..4703805 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PH350_RS23020 (4704227) 4704227..4704610 + 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
PH350_RS23025 (4704607) 4704607..4705125 - 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
PH350_RS23030 (4705129) 4705129..4705398 - 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
PH350_RS23035 (4705576) 4705576..4706679 - 1104 WP_001528146.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PH350_RS23040 (4707001) 4707001..4707855 - 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
PH350_RS23045 (4708101) 4708101..4709156 - 1056 WP_001081707.1 permease-like cell division protein FtsX -
PH350_RS23050 (4709149) 4709149..4709817 - 669 WP_000617729.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4693021..4709817 16796


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T270398 WP_000369560.1 NZ_CP117299:c4705125-4704607 [Salmonella enterica subsp. enterica serovar Mbandaka]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT270398 WP_001275017.1 NZ_CP117299:c4705398-4705129 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References