Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4181523..4182183 Replicon chromosome
Accession NZ_CP117299
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)


Gene name cptA Uniprot ID A0A3V4SJP5
Locus tag PH350_RS20410 Protein ID WP_000244755.1
Coordinates 4181523..4181936 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PH350_RS20415 Protein ID WP_000351186.1
Coordinates 4181917..4182183 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH350_RS20390 (4177464) 4177464..4179197 - 1734 WP_000813392.1 single-stranded-DNA-specific exonuclease RecJ -
PH350_RS20395 (4179203) 4179203..4179916 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PH350_RS20400 (4179940) 4179940..4180836 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PH350_RS20405 (4180949) 4180949..4181470 + 522 WP_017441091.1 flavodoxin FldB -
PH350_RS20410 (4181523) 4181523..4181936 - 414 WP_000244755.1 protein YgfX Toxin
PH350_RS20415 (4181917) 4181917..4182183 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PH350_RS20420 (4182433) 4182433..4183413 + 981 WP_017441090.1 tRNA-modifying protein YgfZ -
PH350_RS20425 (4183529) 4183529..4184188 - 660 WP_000250289.1 hemolysin III family protein -
PH350_RS20430 (4184352) 4184352..4184663 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PH350_RS20435 (4184821) 4184821..4186254 + 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16164.10 Da        Isoelectric Point: 10.2118

>T270395 WP_000244755.1 NZ_CP117299:c4181936-4181523 [Salmonella enterica subsp. enterica serovar Mbandaka]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270395 WP_000351186.1 NZ_CP117299:c4182183-4181917 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SJP5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References