Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4023414..4024228 Replicon chromosome
Accession NZ_CP117299
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3W0Q3Z8
Locus tag PH350_RS19685 Protein ID WP_017441137.1
Coordinates 4023701..4024228 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A418Z520
Locus tag PH350_RS19680 Protein ID WP_017441138.1
Coordinates 4023414..4023704 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH350_RS19650 (4019342) 4019342..4019992 - 651 WP_001728903.1 type III secretion system transcriptional activator InvF -
PH350_RS19655 (4020448) 4020448..4020891 + 444 WP_017441140.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PH350_RS19660 (4021323) 4021323..4021772 + 450 WP_017441139.1 hypothetical protein -
PH350_RS19665 (4021757) 4021757..4022104 + 348 WP_001555786.1 DUF1493 family protein -
PH350_RS19670 (4022377) 4022377..4022703 - 327 WP_000393295.1 hypothetical protein -
PH350_RS19675 (4022944) 4022944..4023144 + 201 Protein_3835 IS3 family transposase -
PH350_RS19680 (4023414) 4023414..4023704 + 291 WP_017441138.1 DUF1778 domain-containing protein Antitoxin
PH350_RS19685 (4023701) 4023701..4024228 + 528 WP_017441137.1 GNAT family N-acetyltransferase Toxin
PH350_RS19690 (4024301) 4024301..4024516 - 216 Protein_3838 IS5/IS1182 family transposase -
PH350_RS19695 (4024854) 4024854..4025510 + 657 WP_017441135.1 protein-serine/threonine phosphatase -
PH350_RS19700 (4025681) 4025681..4026175 - 495 WP_000424947.1 hypothetical protein -
PH350_RS19705 (4026202) 4026202..4026870 - 669 WP_000445914.1 hypothetical protein -
PH350_RS19710 (4027027) 4027027..4027266 - 240 Protein_3842 hypothetical protein -
PH350_RS19715 (4027457) 4027457..4027855 - 399 Protein_3843 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4024301..4024441 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19035.89 Da        Isoelectric Point: 9.6420

>T270394 WP_017441137.1 NZ_CP117299:4023701-4024228 [Salmonella enterica subsp. enterica serovar Mbandaka]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SLKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.55 Da        Isoelectric Point: 8.5957

>AT270394 WP_017441138.1 NZ_CP117299:4023414-4023704 [Salmonella enterica subsp. enterica serovar Mbandaka]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFARPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W0Q3Z8

Antitoxin

Source ID Structure
AlphaFold DB A0A418Z520

References