Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 940190..940880 Replicon chromosome
Accession NC_017573
Organism Serratia sp. AS13

Toxin (Protein)


Gene name tad Uniprot ID A0A7U3YZ62
Locus tag SERAS13_RS04330 Protein ID WP_013811601.1
Coordinates 940506..940880 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A7U3YZ40
Locus tag SERAS13_RS04325 Protein ID WP_013811600.1
Coordinates 940190..940519 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS13_RS04305 936087..937547 - 1461 WP_004948989.1 NCS1 family nucleobase:cation symporter-1 -
SERAS13_RS04310 937714..938463 + 750 WP_013811597.1 GntR family transcriptional regulator -
SERAS13_RS04315 938460..939203 + 744 WP_013811598.1 allantoin racemase -
SERAS13_RS04320 939223..940161 + 939 WP_013811599.1 allantoinase PuuE -
SERAS13_RS04325 940190..940519 - 330 WP_013811600.1 helix-turn-helix domain-containing protein Antitoxin
SERAS13_RS04330 940506..940880 - 375 WP_013811601.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERAS13_RS04335 940986..943181 - 2196 WP_013811602.1 TonB-dependent siderophore receptor -
SERAS13_RS04340 943217..944545 - 1329 WP_013811603.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(16-95)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14031.35 Da        Isoelectric Point: 9.8478

>T27039 WP_013811601.1 NC_017573:c940880-940506 [Serratia sp. AS13]
MDKHQVKQLIWIASSKKDLLSLPEEIIKSMGYTLHWVQAGLTPPGVNPLKGFLGAGVLEKVEDFDGNTYRAVYTVRFEDT
VFVLHCFQKKSKTGISTPKADIEFIKSRLSKAKQIYEDMKNGKI

Download         Length: 375 bp

>T27039 NC_017573:c940880-940506 [Serratia sp. AS13]
ATGGATAAGCACCAAGTAAAACAGCTGATATGGATAGCAAGCAGTAAAAAAGACCTGCTTTCGCTGCCTGAAGAAATTAT
TAAATCAATGGGTTATACCCTACATTGGGTTCAGGCGGGATTAACGCCACCCGGAGTGAACCCCTTAAAGGGATTTCTGG
GTGCTGGCGTATTGGAAAAGGTTGAGGATTTTGACGGTAACACCTACCGGGCAGTTTATACCGTGCGGTTCGAAGACACT
GTATTTGTGCTCCACTGCTTTCAGAAAAAATCCAAAACAGGAATTTCAACGCCAAAGGCGGACATTGAATTCATCAAGTC
TCGCCTGAGCAAAGCCAAACAGATTTACGAGGACATGAAAAATGGCAAAATATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12261.17 Da        Isoelectric Point: 6.3033

>AT27039 WP_013811600.1 NC_017573:c940519-940190 [Serratia sp. AS13]
MAKYDENDFEIGSDNIFADLKLPDAENLKLKADLAIKIINTIQQLGLNQVEAGKRMNLPQARVSALYNGKFFNMSEQKLM
ICLNRLGYDIEIIVKPSQNTVGQRTLSVT

Download         Length: 330 bp

>AT27039 NC_017573:c940519-940190 [Serratia sp. AS13]
ATGGCAAAATATGACGAAAATGATTTTGAGATCGGTTCGGACAACATTTTTGCTGATTTAAAACTGCCTGATGCAGAAAA
CCTTAAACTAAAGGCCGATCTCGCCATCAAAATTATCAATACAATTCAACAGCTAGGACTCAACCAAGTAGAAGCGGGCA
AACGAATGAACCTGCCACAGGCACGAGTTTCCGCGTTGTATAACGGCAAATTTTTCAATATGTCAGAGCAAAAGCTGATG
ATCTGCCTCAACCGACTCGGTTACGACATAGAAATTATCGTCAAACCCAGCCAGAACACCGTCGGCCAGCGTACCCTTTC
AGTGACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3YZ62

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3YZ40

References