270388

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2665640..2666162 Replicon chromosome
Accession NZ_CP117299
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag PH350_RS13050 Protein ID WP_000221345.1
Coordinates 2665640..2665924 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PH350_RS13055 Protein ID WP_000885424.1
Coordinates 2665914..2666162 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH350_RS13030 (2661715) 2661715..2663223 - 1509 WP_017441357.1 FAD-dependent oxidoreductase -
PH350_RS13035 (2663268) 2663268..2663756 + 489 WP_017441356.1 MarR family winged helix-turn-helix transcriptional regulator -
PH350_RS13040 (2663949) 2663949..2665022 + 1074 WP_017441355.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PH350_RS13045 (2665080) 2665080..2665469 - 390 WP_001652798.1 RidA family protein -
PH350_RS13050 (2665640) 2665640..2665924 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PH350_RS13055 (2665914) 2665914..2666162 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PH350_RS13060 (2666575) 2666575..2666928 - 354 WP_000418733.1 hypothetical protein -
PH350_RS13065 (2666931) 2666931..2667320 - 390 WP_017441353.1 hypothetical protein -
PH350_RS13070 (2667685) 2667685..2667801 + 117 Protein_2544 IS110 family transposase -
PH350_RS13075 (2668324) 2668324..2668656 + 333 WP_017441352.1 DUF1493 family protein -
PH350_RS13080 (2668929) 2668929..2669837 + 909 WP_077906523.1 hypothetical protein -
PH350_RS13085 (2669839) 2669839..2670619 - 781 Protein_2547 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2663949..2675368 11419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T270388 WP_000221345.1 NZ_CP117299:c2665924-2665640 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270388 WP_000885424.1 NZ_CP117299:c2666162-2665914 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References