Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1623783..1624403 Replicon chromosome
Accession NZ_CP117299
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PH350_RS07815 Protein ID WP_001280991.1
Coordinates 1623783..1624001 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PH350_RS07820 Protein ID WP_000344807.1
Coordinates 1624029..1624403 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH350_RS07775 (1619008) 1619008..1619577 + 570 WP_000779801.1 YbaY family lipoprotein -
PH350_RS07780 (1619610) 1619610..1619999 - 390 WP_000961285.1 MGMT family protein -
PH350_RS07790 (1620230) 1620230..1621780 - 1551 WP_000213140.1 EAL domain-containing protein -
PH350_RS07795 (1622005) 1622005..1622265 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PH350_RS07800 (1622271) 1622271..1622411 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PH350_RS07805 (1622467) 1622467..1622937 - 471 WP_000136183.1 YlaC family protein -
PH350_RS07810 (1623053) 1623053..1623604 - 552 WP_001278793.1 maltose O-acetyltransferase -
PH350_RS07815 (1623783) 1623783..1624001 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PH350_RS07820 (1624029) 1624029..1624403 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PH350_RS07825 (1624899) 1624899..1628048 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PH350_RS07830 (1628071) 1628071..1629264 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270387 WP_001280991.1 NZ_CP117299:c1624001-1623783 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270387 WP_000344807.1 NZ_CP117299:c1624403-1624029 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References