270380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1045757..1047380 Replicon chromosome
Accession NZ_CP117299
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag PH350_RS05025 Protein ID WP_000088046.1
Coordinates 1045757..1047082 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag PH350_RS05030 Protein ID WP_024136327.1
Coordinates 1047087..1047380 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH350_RS04985 (1040778) 1040778..1041134 + 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -
PH350_RS04990 (1041476) 1041476..1041679 - 204 WP_001194555.1 hypothetical protein -
PH350_RS04995 (1041741) 1041741..1042598 - 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
PH350_RS05000 (1042614) 1042614..1042922 - 309 WP_001224687.1 hypothetical protein -
PH350_RS05005 (1043471) 1043471..1043896 - 426 WP_001043843.1 hypothetical protein -
PH350_RS05010 (1044150) 1044150..1044965 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
PH350_RS05015 (1044978) 1044978..1045388 - 411 WP_000985911.1 hypothetical protein -
PH350_RS05020 (1045490) 1045490..1045696 - 207 WP_000134171.1 hypothetical protein -
PH350_RS05025 (1045757) 1045757..1047082 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
PH350_RS05030 (1047087) 1047087..1047380 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
PH350_RS05035 (1047820) 1047820..1048524 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
PH350_RS05040 (1048576) 1048576..1048698 - 123 Protein_970 IS4 family transposase -
PH350_RS05045 (1048841) 1048841..1049701 + 861 WP_000557454.1 aminoglycoside N-acetyltransferase AAC(3)-IId -
PH350_RS05050 (1049714) 1049714..1050256 + 543 WP_000587837.1 AAA family ATPase -
PH350_RS05055 (1050738) 1050738..1050929 - 192 WP_000951934.1 hypothetical protein -
PH350_RS05060 (1050953) 1050953..1051180 + 228 WP_000248278.1 hypothetical protein -
PH350_RS05065 (1051231) 1051231..1052358 + 1128 WP_014837927.1 DUF3883 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T270380 WP_000088046.1 NZ_CP117299:c1047082-1045757 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T270380 NZ_CP117299:c1047082-1045757 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT270380 WP_024136327.1 NZ_CP117299:c1047380-1047087 [Salmonella enterica subsp. enterica serovar Mbandaka]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT270380 NZ_CP117299:c1047380-1047087 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References