Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 837655..838298 Replicon chromosome
Accession NZ_CP117299
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag PH350_RS04025 Protein ID WP_017441191.1
Coordinates 837655..838071 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PH350_RS04030 Protein ID WP_001261294.1
Coordinates 838068..838298 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH350_RS04005 (832692) 832692..833825 + 1134 WP_017441192.1 amidohydrolase/deacetylase family metallohydrolase -
PH350_RS04010 (833809) 833809..834927 + 1119 WP_001139194.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PH350_RS04015 (834924) 834924..835664 + 741 WP_023229489.1 KDGP aldolase family protein -
PH350_RS04020 (835681) 835681..837594 + 1914 WP_023242878.1 BglG family transcription antiterminator -
PH350_RS04025 (837655) 837655..838071 - 417 WP_017441191.1 type II toxin-antitoxin system VapC family toxin Toxin
PH350_RS04030 (838068) 838068..838298 - 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PH350_RS04035 (838465) 838465..838929 - 465 WP_017441190.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PH350_RS04040 (839146) 839146..841284 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15163.55 Da        Isoelectric Point: 8.1381

>T270378 WP_017441191.1 NZ_CP117299:c838071-837655 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAVGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT270378 WP_001261294.1 NZ_CP117299:c838298-838068 [Salmonella enterica subsp. enterica serovar Mbandaka]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References