Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3772451..3773136 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag PQK93_RS17695 Protein ID WP_003417998.1
Coordinates 3772726..3773136 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PQK93_RS17690 Protein ID WP_003912220.1
Coordinates 3772451..3772729 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS17670 (PQK93_17670) 3768440..3770041 - 1602 WP_057137841.1 FAD/NAD(P)-binding protein -
PQK93_RS17675 (PQK93_17675) 3770058..3770762 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
PQK93_RS17680 (PQK93_17680) 3770880..3771446 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
PQK93_RS17685 (PQK93_17685) 3771508..3772395 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
PQK93_RS17690 (PQK93_17690) 3772451..3772729 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQK93_RS17695 (PQK93_17695) 3772726..3773136 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
PQK93_RS17700 (PQK93_17700) 3773169..3774905 - 1737 WP_003418002.1 cholesterol oxidase -
PQK93_RS17705 (PQK93_17705) 3774961..3776088 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
PQK93_RS17710 (PQK93_17710) 3776108..3777697 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T270374 WP_003417998.1 NZ_CP117298:3772726-3773136 [Mycobacterium tuberculosis variant bovis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT270374 WP_003912220.1 NZ_CP117298:3772451-3772729 [Mycobacterium tuberculosis variant bovis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References