Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3745189..3745856 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag PQK93_RS17575 Protein ID WP_003417916.1
Coordinates 3745189..3745581 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag PQK93_RS17580 Protein ID WP_003912214.1
Coordinates 3745581..3745856 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS17560 (PQK93_17560) 3740559..3742397 - 1839 WP_023349617.1 1-deoxy-D-xylulose-5-phosphate synthase -
PQK93_RS17565 (PQK93_17565) 3742394..3743383 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
PQK93_RS17570 (PQK93_17570) 3743383..3744435 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
PQK93_RS17575 (PQK93_17575) 3745189..3745581 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
PQK93_RS17580 (PQK93_17580) 3745581..3745856 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQK93_RS17585 (PQK93_17585) 3746038..3747409 + 1372 Protein_3473 ISNCY family transposase -
PQK93_RS17590 (PQK93_17590) 3747599..3749851 + 2253 WP_274479584.1 PE family protein -
PQK93_RS17595 (PQK93_17595) 3749922..3750794 - 873 WP_010950882.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3746732..3747409 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T270373 WP_003417916.1 NZ_CP117298:c3745581-3745189 [Mycobacterium tuberculosis variant bovis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT270373 WP_003912214.1 NZ_CP117298:c3745856-3745581 [Mycobacterium tuberculosis variant bovis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References