Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3718067..3718596 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag PQK93_RS17455 Protein ID WP_003417760.1
Coordinates 3718339..3718596 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag PQK93_RS17450 Protein ID WP_003417757.1
Coordinates 3718067..3718342 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS17415 (PQK93_17415) 3714640..3715329 - 690 WP_003917774.1 BBE domain-containing protein -
PQK93_RS17420 (PQK93_17420) 3715516..3715887 - 372 WP_003417739.1 FAD-binding protein -
PQK93_RS17425 (PQK93_17425) 3715785..3716003 - 219 WP_157132559.1 hypothetical protein -
PQK93_RS17430 (PQK93_17430) 3716030..3716290 - 261 WP_003417741.1 hypothetical protein -
PQK93_RS17435 (PQK93_17435) 3716405..3716794 + 390 WP_010950876.1 DUF732 domain-containing protein -
PQK93_RS17440 (PQK93_17440) 3716808..3717101 - 294 WP_003417749.1 DUF3017 domain-containing protein -
PQK93_RS17445 (PQK93_17445) 3717098..3717943 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
PQK93_RS17450 (PQK93_17450) 3718067..3718342 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
PQK93_RS17455 (PQK93_17455) 3718339..3718596 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
PQK93_RS17460 (PQK93_17460) 3718638..3719828 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
PQK93_RS17465 (PQK93_17465) 3719945..3720313 + 369 WP_003417765.1 FHA domain-containing protein -
PQK93_RS17470 (PQK93_17470) 3720310..3720861 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
PQK93_RS17475 (PQK93_17475) 3720868..3721449 - 582 WP_003417769.1 ATP/GTP-binding protein -
PQK93_RS17480 (PQK93_17480) 3721430..3721798 - 369 WP_003417772.1 DUF742 domain-containing protein -
PQK93_RS17485 (PQK93_17485) 3721776..3722168 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T270372 WP_003417760.1 NZ_CP117298:3718339-3718596 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT270372 WP_003417757.1 NZ_CP117298:3718067-3718342 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References