Detailed information of TA system TA027037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 555056..556605
• Replicon: chromosome
• Accession: NC_017573
• Organism: Serratia sp. AS13

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7U3YYG4
• Locus tag: SERAS13_RS02595
• Protein ID: WP_013811338.1
• Coordinates: 555307..556605 (+)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SERAS13_RS02590
• Protein ID: WP_004953056.1
• Coordinates: 555056..555304 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SERAS13_RS02565	550271..551341	+	1071	WP_013811333.1	LPS export ABC transporter permease LptG	-
SERAS13_RS25260	551835..552050	+	216	WP_013811334.1	hypothetical protein	-
SERAS13_RS02575	552083..552784	-	702	WP_013811335.1	hypothetical protein	-
SERAS13_RS02580	553124..553759	+	636	WP_013811336.1	carbonic anhydrase	-
SERAS13_RS02585	554189..554647	-	459	WP_013811337.1	hypothetical protein	-
SERAS13_RS02590	555056..555304	+	249	WP_004953056.1	helix-turn-helix domain-containing protein	Antitoxin
SERAS13_RS02595	555307..556605	+	1299	WP_013811338.1	type II toxin-antitoxin system HipA family toxin	Toxin
SERAS13_RS02600	557290..559926	+	2637	WP_013811339.1	Z1 domain-containing protein	-
SERAS13_RS25270	559932..560930	+	999	WP_013811340.1	PD-(D/E)XK motif protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	555056..569590	14534

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-399)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 48216.28 Da
• Isoelectric Point: 5.6236

>T27037 WP_013811338.1 NC_017573:555307-556605 [Serratia sp. AS13]
MEKLRVALNGTVVGTLEKHAGGAMSFVYHEEWLAQAGARAISLSLPLQPEPFRGDVVYNFFDNLLPDSELIRSRLQARFK
TATKQPFDLLSSIGSDCVGAIQLYPEHADVAPVKQVNAVPVSDEEIEQLLLGYREAPLGMEAGIDDFRISLAGAQEKTAL
LWFGNQWCRPQGSTPTSHIIKLPIGHIAHNNLDLSESCENEWLCLRIAEQFGLPVAQAELAHFGEQKVLIVERFDRRWAR
DNSWLIRLPQEDFCQALGIAHALKYEADGGPGIAAAMELLLGSQQPLLDRDIFFKSQIVFWMLAAIDGHAKNFSLFIEQE
TAYRMTPLYDVLSGYPFMNARGIAPQKAKMAMAVLGQSRHYRWSQILPRHFISTARAVGYSEEKTLQVMAELKAQTEQAI
ANVEAMLPDEFPRLVSDAIFAGVRRQAERLVG

Nucleotide

• Length: 1299 bp

>T27037 NC_017573:555307-556605 [Serratia sp. AS13]
ATGGAAAAGCTACGTGTGGCGCTGAATGGCACTGTTGTTGGGACGCTGGAAAAGCACGCGGGCGGCGCGATGTCGTTTGT
TTACCACGAAGAGTGGCTGGCACAAGCCGGTGCGCGCGCCATATCGTTATCCCTGCCGCTACAACCAGAACCGTTTCGCG
GTGACGTGGTGTATAACTTTTTCGACAACCTGCTGCCGGACAGCGAACTTATTCGCAGCCGCCTACAGGCGCGTTTTAAA
ACGGCAACCAAACAGCCTTTTGATCTGCTTTCCAGCATTGGCAGCGACTGCGTGGGTGCGATCCAGCTTTACCCTGAACA
TGCCGATGTGGCCCCGGTCAAGCAAGTGAACGCCGTGCCTGTCAGTGACGAAGAAATAGAGCAACTTCTGCTGGGGTACC
GCGAGGCACCGCTGGGCATGGAGGCGGGTATTGATGATTTCCGGATCTCTCTGGCGGGTGCGCAGGAAAAGACCGCGCTG
CTTTGGTTCGGCAATCAGTGGTGTCGGCCACAGGGGAGTACGCCAACCAGCCACATCATAAAACTGCCCATTGGGCATAT
TGCACATAACAATTTGGATCTCAGTGAAAGCTGTGAGAACGAGTGGTTATGTTTGCGCATTGCAGAACAGTTTGGCCTGC
CGGTAGCGCAGGCTGAGTTGGCGCATTTTGGCGAGCAGAAGGTCCTGATCGTTGAGCGTTTTGACCGGCGTTGGGCGCGG
GATAACAGTTGGCTGATTCGTTTGCCGCAGGAGGATTTTTGCCAGGCGTTAGGCATTGCTCATGCGCTGAAATATGAGGC
TGATGGTGGGCCCGGTATTGCGGCTGCTATGGAGTTGCTATTGGGCTCTCAACAACCCTTGCTCGATCGGGACATTTTCT
TTAAAAGCCAAATCGTATTCTGGATGCTGGCGGCCATTGATGGGCATGCCAAAAACTTTAGCCTGTTCATTGAGCAGGAA
ACGGCCTATCGAATGACTCCGCTTTACGATGTGCTCTCGGGTTACCCATTCATGAACGCCCGTGGCATCGCGCCGCAGAA
AGCAAAAATGGCCATGGCCGTGCTGGGGCAAAGTCGCCATTACCGTTGGAGCCAGATCTTGCCTCGGCACTTTATCTCTA
CCGCGAGAGCGGTGGGGTATTCCGAAGAGAAAACGCTGCAGGTGATGGCTGAGCTAAAAGCGCAAACGGAGCAGGCGATC
GCTAATGTGGAAGCGATGCTGCCGGATGAGTTTCCTCGTCTCGTGAGTGATGCGATTTTTGCTGGGGTTCGGCGGCAGGC
TGAGAGGTTGGTGGGGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9263.60 Da
• Isoelectric Point: 10.4887

>AT27037 WP_004953056.1 NC_017573:555056-555304 [Serratia sp. AS13]
MKITSAKMLAHALRNERKKRNQSQSKTADSIGLKQATVSAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Nucleotide

• Length: 249 bp

>AT27037 NC_017573:555056-555304 [Serratia sp. AS13]
ATGAAAATCACCTCGGCAAAGATGTTGGCGCATGCGCTACGCAATGAGCGTAAAAAGCGTAACCAGAGCCAAAGCAAAAC
CGCTGACAGCATCGGATTAAAACAGGCCACGGTTTCCGCCTTTGAAAACAACCCGGACGGCACCCGGCTGGAGACGTTGT
TTAAACTGCTTGCTGCGCTGGATTTAGAGCTACAAGTGACTCCGCGCGGTAAGCCGGTCGATCCCAAAACCTGGGATCAG
GAGTGGTGA

Structures

Toxin

• AlphaFold DB: A0A7U3YYG4