Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3127706..3128254 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag PQK93_RS14865 Protein ID WP_003414602.1
Coordinates 3127991..3128254 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag PQK93_RS14860 Protein ID WP_003414599.1
Coordinates 3127706..3127987 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS14835 (PQK93_14835) 3123329..3124186 - 858 WP_003899513.1 type I methionyl aminopeptidase -
PQK93_RS14840 (PQK93_14840) 3124228..3124812 - 585 WP_010950792.1 DUF1707 domain-containing protein -
PQK93_RS14845 (PQK93_14845) 3124916..3125164 + 249 WP_003913411.1 antitoxin VapB23 -
PQK93_RS14850 (PQK93_14850) 3125161..3125541 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
PQK93_RS14855 (PQK93_14855) 3125623..3127434 - 1812 WP_003414596.1 penicillin-binding protein -
PQK93_RS14860 (PQK93_14860) 3127706..3127987 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
PQK93_RS14865 (PQK93_14865) 3127991..3128254 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQK93_RS14870 (PQK93_14870) 3128627..3129481 - 855 WP_105537264.1 GNAT family N-acetyltransferase -
PQK93_RS14875 (PQK93_14875) 3129537..3130700 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
PQK93_RS14880 (PQK93_14880) 3130717..3131931 - 1215 WP_003414610.1 zinc metalloprotease Rip -
PQK93_RS14885 (PQK93_14885) 3131939..3133180 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T270368 WP_003414602.1 NZ_CP117298:3127991-3128254 [Mycobacterium tuberculosis variant bovis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT270368 WP_003414599.1 NZ_CP117298:3127706-3127987 [Mycobacterium tuberculosis variant bovis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References