Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2339153..2339848 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag PQK93_RS10905 Protein ID WP_003410811.1
Coordinates 2339153..2339587 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag PQK93_RS10910 Protein ID WP_003410814.1
Coordinates 2339594..2339848 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS10895 (PQK93_10895) 2335307..2338348 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
PQK93_RS10900 (PQK93_10900) 2338341..2339174 + 834 WP_003899172.1 SWIM zinc finger family protein -
PQK93_RS10905 (PQK93_10905) 2339153..2339587 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
PQK93_RS10910 (PQK93_10910) 2339594..2339848 - 255 WP_003410814.1 antitoxin Antitoxin
PQK93_RS10915 (PQK93_10915) 2339864..2340121 - 258 WP_003410816.1 hypothetical protein -
PQK93_RS10920 (PQK93_10920) 2341068..2341364 + 297 WP_003410820.1 PE family protein -
PQK93_RS10925 (PQK93_10925) 2341420..2342151 + 732 WP_003900467.1 PPE family protein -
PQK93_RS10930 (PQK93_10930) 2342691..2343437 - 747 WP_105537240.1 proteasome subunit alpha -
PQK93_RS10935 (PQK93_10935) 2343434..2344309 - 876 WP_003411023.1 proteasome subunit beta -
PQK93_RS10940 (PQK93_10940) 2344306..2344500 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T270355 WP_003410811.1 NZ_CP117298:c2339587-2339153 [Mycobacterium tuberculosis variant bovis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT270355 WP_003410814.1 NZ_CP117298:c2339848-2339594 [Mycobacterium tuberculosis variant bovis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References