Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2297971..2298607 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag PQK93_RS10720 Protein ID WP_003410654.1
Coordinates 2298197..2298607 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag PQK93_RS10715 Protein ID WP_003410651.1
Coordinates 2297971..2298204 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS10700 (PQK93_10700) 2293428..2293820 + 393 WP_237085715.1 metal ABC transporter permease -
PQK93_RS10705 (PQK93_10705) 2293821..2294225 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
PQK93_RS10710 (PQK93_10710) 2294309..2297893 - 3585 WP_010950652.1 cobaltochelatase subunit CobN -
PQK93_RS10715 (PQK93_10715) 2297971..2298204 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
PQK93_RS10720 (PQK93_10720) 2298197..2298607 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
PQK93_RS10725 (PQK93_10725) 2298591..2299682 + 1092 WP_003900454.1 precorrin-3B synthase -
PQK93_RS10730 (PQK93_10730) 2299692..2300318 + 627 WP_003410658.1 precorrin-8X methylmutase -
PQK93_RS10735 (PQK93_10735) 2300315..2301841 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
PQK93_RS10740 (PQK93_10740) 2301787..2303010 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T270354 WP_003410654.1 NZ_CP117298:2298197-2298607 [Mycobacterium tuberculosis variant bovis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT270354 WP_003410651.1 NZ_CP117298:2297971-2298204 [Mycobacterium tuberculosis variant bovis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References