Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2230185..2230811 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag PQK93_RS10430 Protein ID WP_003410075.1
Coordinates 2230413..2230811 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PQK93_RS10425 Protein ID WP_019283586.1
Coordinates 2230185..2230412 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS10415 (PQK93_10415) 2228224..2228568 - 345 WP_003410065.1 ferredoxin family protein -
PQK93_RS10420 (PQK93_10420) 2228757..2229926 - 1170 WP_003899126.1 ATP-binding protein -
PQK93_RS10425 (PQK93_10425) 2230185..2230412 + 228 WP_019283586.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQK93_RS10430 (PQK93_10430) 2230413..2230811 + 399 WP_003410075.1 PIN domain nuclease Toxin
PQK93_RS10435 (PQK93_10435) 2230994..2231425 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
PQK93_RS10440 (PQK93_10440) 2231574..2231960 + 387 WP_003899128.1 DUF1398 domain-containing protein -
PQK93_RS10445 (PQK93_10445) 2232397..2232576 - 180 Protein_2064 hypothetical protein -
PQK93_RS10450 (PQK93_10450) 2232664..2233284 + 621 WP_003410086.1 IS110 family transposase -
PQK93_RS10455 (PQK93_10455) 2233238..2233828 + 591 WP_003899131.1 IS110 family transposase -
PQK93_RS10460 (PQK93_10460) 2233956..2235212 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T270352 WP_003410075.1 NZ_CP117298:2230413-2230811 [Mycobacterium tuberculosis variant bovis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.14 Da        Isoelectric Point: 4.0995

>AT270352 WP_019283586.1 NZ_CP117298:2230185-2230412 [Mycobacterium tuberculosis variant bovis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSDDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure

References