Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2204878..2205776 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag PQK93_RS10305 Protein ID WP_003410001.1
Coordinates 2204878..2205438 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag PQK93_RS10310 Protein ID WP_003410003.1
Coordinates 2205435..2205776 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS10275 (PQK93_10275) 2200047..2200700 - 654 WP_003409976.1 cutinase Cfp21 -
PQK93_RS10280 (PQK93_10280) 2200815..2201045 + 231 WP_003409980.1 DUF167 domain-containing protein -
PQK93_RS10285 (PQK93_10285) 2201130..2202041 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
PQK93_RS10290 (PQK93_10290) 2202150..2202749 + 600 WP_003409989.1 L-lysine exporter -
PQK93_RS10295 (PQK93_10295) 2203165..2203593 + 429 WP_003409992.1 cellulose-binding protein -
PQK93_RS10300 (PQK93_10300) 2203819..2204358 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
PQK93_RS10305 (PQK93_10305) 2204878..2205438 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
PQK93_RS10310 (PQK93_10310) 2205435..2205776 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
PQK93_RS10315 (PQK93_10315) 2205862..2206119 + 258 WP_003410006.1 hypothetical protein -
PQK93_RS10320 (PQK93_10320) 2206020..2206355 - 336 WP_003410009.1 dehydrogenase -
PQK93_RS10325 (PQK93_10325) 2206445..2206789 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
PQK93_RS10330 (PQK93_10330) 2206783..2207031 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
PQK93_RS10335 (PQK93_10335) 2207131..2209446 - 2316 WP_003899120.1 cation transporter ATPase CptG -
PQK93_RS10340 (PQK93_10340) 2209443..2209715 - 273 WP_003410017.1 DUF1490 family protein -
PQK93_RS10345 (PQK93_10345) 2209768..2210124 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T270350 WP_003410001.1 NZ_CP117298:c2205438-2204878 [Mycobacterium tuberculosis variant bovis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT270350 WP_003410003.1 NZ_CP117298:c2205776-2205435 [Mycobacterium tuberculosis variant bovis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References