Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 57313..57848 Replicon chromosome
Accession NC_017573
Organism Serratia sp. AS13

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3YXN3
Locus tag SERAS13_RS00260 Protein ID WP_013810970.1
Coordinates 57573..57848 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U3YXM9
Locus tag SERAS13_RS00255 Protein ID WP_013810969.1
Coordinates 57313..57573 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS13_RS00235 52647..53288 + 642 WP_013810965.1 DcrB-related protein -
SERAS13_RS00240 53324..53929 + 606 WP_013810966.1 glutathione S-transferase -
SERAS13_RS00245 54000..55391 + 1392 WP_013810967.1 L-seryl-tRNA(Sec) selenium transferase -
SERAS13_RS00250 55388..57229 + 1842 WP_013810968.1 selenocysteine-specific translation elongation factor -
SERAS13_RS00255 57313..57573 + 261 WP_013810969.1 ribbon-helix-helix domain-containing protein Antitoxin
SERAS13_RS00260 57573..57848 + 276 WP_013810970.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERAS13_RS00265 57910..59157 - 1248 WP_013810971.1 MFS transporter -
SERAS13_RS00270 59377..60369 + 993 WP_013810972.1 acyltransferase -
SERAS13_RS00275 60364..61287 - 924 WP_013810973.1 DJ-1/PfpI family protein -
SERAS13_RS00280 61287..61841 - 555 WP_013810974.1 isochorismatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10684.39 Da        Isoelectric Point: 10.0332

>T27035 WP_013810970.1 NC_017573:57573-57848 [Serratia sp. AS13]
MELKWTSKALSDLARLFDFLAPVNRTAAANTIQALVAAPKVLRDNPRIGEKLDEFMPQEVRRILVGHYEMRYQLQSSTIY
VLRIWHTREER

Download         Length: 276 bp

>T27035 NC_017573:57573-57848 [Serratia sp. AS13]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGATTTTCTTGCCCCGGTTAACCGTACTGC
CGCAGCTAACACGATACAGGCTTTGGTTGCAGCACCTAAGGTACTGCGTGATAACCCCCGTATTGGCGAGAAACTGGATG
AATTTATGCCGCAGGAGGTGAGGCGTATCCTCGTCGGTCATTATGAAATGCGCTACCAACTTCAATCCTCAACAATTTAT
GTCCTGCGTATTTGGCATACGCGCGAAGAGCGTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9769.17 Da        Isoelectric Point: 4.8430

>AT27035 WP_013810969.1 NC_017573:57313-57573 [Serratia sp. AS13]
MNTKVITAHVPLPLADKVDEMAAKLERSRGWIIKQALAAWLDQEEERRRLTLEALADVEQQNIIDHESVETWAVSLSSDK
PLPVPR

Download         Length: 261 bp

>AT27035 NC_017573:57313-57573 [Serratia sp. AS13]
ATGAATACTAAAGTCATCACCGCACATGTGCCGTTACCCTTAGCGGACAAAGTTGATGAGATGGCCGCTAAACTGGAACG
TTCGCGCGGATGGATCATTAAGCAGGCCCTTGCCGCATGGCTCGATCAAGAAGAAGAACGTCGCCGTTTAACATTGGAGG
CCCTCGCCGATGTCGAACAGCAAAATATCATCGACCATGAATCGGTAGAAACCTGGGCCGTAAGCCTGAGCAGCGATAAG
CCTTTACCGGTACCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3YXN3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3YXM9

References